Role of clonally-related neurons in hippocampal neuronal circuit

2014 Fiscal Year Final Research Report

• Project/Area Number: 26640020
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neurophysiology / General neuroscience
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: HAYASHI Yasunori 独立行政法人理化学研究所, 脳科学総合研究センター, チームリーダー (90466037)
• Project Period (FY): 2014-04-01 – 2015-03-31
• Keywords: 神経科学 / 脳・神経

Outline of Final Research Achievements

The cluster of neurons which differentiated from progenitor cells are called clonally-related neurons. In this study, we analyzed neuronal activity of clonally-related neurons using Ca2+ sensor protein and retrovirus vector for labeling clonally-related neurons. At 12 days after fertilization, retrovirus was injected into subventricular zone through uterine wall. Infected neurons in hippocampal CA1 region were imaged using two photon microscope at 2 month later after birth and we can see the clonally-related neurons in hippocampal CA1 region. When we analyse the neuronal activity in clonally-related neurons, it is indicated that firing rate of clonally-related neurons were lower than other neurons.

Free Research Field

総合生物