Molecular mechanisms to control morphologies of postmitotic neurons

2015 Fiscal Year Final Research Report

• Project/Area Number: 26640026
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Chiba University
• Principal Investigator: SAITO Tetsuichiro 千葉大学, 医学(系)研究科(研究院), 教授 (00202078)
• Co-Investigator(Renkei-kenkyūsha): MUROYAMA Yuko 千葉大学, 大学院医学研究院, 特任講師 (20422248)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 遺伝子 / 細胞・組織 / 神経科学 / 脳・神経 / 発生・分化 / 神経細胞 / 電気穿孔法 / テトラサイクリン

Outline of Final Research Achievements

Neurons are distinguished by morphologies typical of their subtypes. To unravel molecular mechanisms to control the subtype-specific morphologies, we have developed the gene expression system in which a gene of interest is specifically induced in postmitotic neurons in vivo. We have also found that Nepro, which is necessary for the maintenance of neural progenitors in the early forebrain, is localized in the nucleolus in the developing embryo.

Free Research Field

神経科学