2015 Fiscal Year Final Research Report
Heterogeneity of TDP-43 pathology and clinicopathologic correlations in sporadic amyotrophic lateral sclerosis
| Project/Area Number |
26640029
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TOYOSHIMA Yasuko 新潟大学, 脳研究所, 准教授 (20334675)
TADA Mari 新潟大学, 脳研究所, 助教 (30646394)
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| Co-Investigator(Renkei-kenkyūsha) |
ONODERA Osamu 新潟大学, 脳研究所, 教授 (20303167)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 神経変性疾患 / 筋萎縮性側索硬化症 / TDP-43 / 病型分類 / 免疫組織化学 |
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| Outline of Final Research Achievements |
A nuclear protein,TDP-43, is the major pathological protein in ALS. We attempted to clarify the corticalpathology in cases of sporadic amyotrophic lateral sclerosis (ALS: n = 96) using an antibody specific to phosphorylated TDP-43 (pTDP-43). The cases were divided into two groups: those without pTDP-43-positive neuronal cytoplasmic inclusions in the hippocampal dentate granule cells (classical ALS: ALS-C, n = 63), and those with such inclusions (ALS with temporal lesions: ALS-T, n = 33). Furthermore, the ALS-T cases were divided into two subgroups based on semi-quantitative estimation of pTDP-43-positive dystrophic neurites (DNs) in the temporal neocortex: ALS-T/few DNs (n = 22) and ALS-T/many DNs (n = 11). Considering the patient survival time and severity of motor neuron loss in each group, transition from ALS-C to ALS-T, or from ALS-T/few DNs to ALS-T/many DNs during the disease course appeared unlikely. Therefore, each of these three groups was regarded as an independent subtype.
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| Free Research Field |
神経病理学
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