Effects of tubulin acetylation on tauopathy in brain

2015 Fiscal Year Final Research Report

• Project/Area Number: 26640030
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Doshisha University
• Principal Investigator: Kubo Atsuko 同志社大学, 生命医科学部, 特別研究員 (70647792)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: タウ / タウオパチー / 微小管 / アルツハイマー病

Outline of Final Research Achievements

Tau, a microtubule-associated protein, is the major component of neurofibrillary tangles (NFTs) in Alzheimer's disease (AD) and related disorders called tauopathies. Tau is localized in neuronal axons and stabilizes microtubules in physiological conditions. In AD, Tau miss-localized into the somatodendritic compartment and microtubules are destabilized. To determine how the pathogenesis of tauopathy occurs, we investigated the detailed localization of physiological tau in mouse brain by new immunohistochemical technique that we developed. We further found that the abnormal distribution of exogenous tau expression appeared only in the tau transgenic mice.

Free Research Field

総合生物