Relationship between blood flow and neuronal regenerataion

2015 Fiscal Year Final Research Report

• Project/Area Number: 26640046
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Nagoya City University
• Principal Investigator: Sawamoto Kazunobu 名古屋市立大学, 医学(系)研究科(研究院), 教授 (90282350)
• Co-Investigator(Renkei-kenkyūsha): KANEKO Naoko 名古屋市立大学, 医学研究科, 講師 (20464571) ; SAWADA Masato 名古屋市立大学, 医学研究科, 助教 (20645288)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 再生医学 / 神経科学 / 脳・神経 / 脳神経疾患

Outline of Final Research Achievements

To study the relationship between neuronal regeneration and blood flow, we performed in vivo live imaging using a two-photon laser microscope. Using transgenic mice that express a fluorescent protein in a subtype of neurons, we observed the same new neurons in the olfactory bulbs twice with an interval of four weeks. Simultaneously, we injected a green fluorescent dye intravenously to image and measure blood flow. Our results suggest that blood flow correlates with the neuronal regeneration efficiency.

Free Research Field

再生医学