2015 Fiscal Year Final Research Report
Generation of induction method of insulin producing cells from mouse liver cells in vivo
Project/Area Number |
26640049
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Laboratory animal science
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Research Institution | University of Tsukuba |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Keywords | インスリン / β細胞 / 再生 / ダイレクトリプログラミング |
Outline of Final Research Achievements |
In order to develop a method that induces insulin-producing cells from the liver cells in living mice, we genarated conditinally over-expressing mice of Pdx1, NeuroD and MafA. Furthermore, We identifed a new factor that enhances the production of insulin from mouse liver cells with Pdx1, NeuroD and MafA. The new factor could enhance insulin transcription approximately 10-fold.
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Free Research Field |
実験動物学
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