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2014 Fiscal Year Final Research Report

The membrane potential and signal transduction of non excitable epithelial cells.

Research Project

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Project/Area Number 26640057
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Laboratory animal science
Research InstitutionOsaka University

Principal Investigator

TAMURA Atsushi  大阪大学, 生命機能研究科, 准教授 (00362525)

Project Period (FY) 2014-04-01 – 2015-03-31
Keywordsタイトジャンクション / クローディン / 微小環境 / 電流 / 膜電位 / 上皮細胞
Outline of Final Research Achievements

The effects of ion or water permeability through epithelial tight junction is not well understood.
In this research, the aim is to clarify the biological functions and it's mechanisms regulated directly or indirectly by the properties of intercellular tight junction in epithelial cells.One of the most interesting biological function is pH dependency, especially dependency of lower pH of basal side culture medium on TER. It suggests there is some special mechanism which works as a sensor residing only in basal side of cells.

Free Research Field

細胞生物学

URL: 

Published: 2016-06-03  

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