2015 Fiscal Year Final Research Report
Can short-lived African medaka be a model of neuropsychiatric disease ?
| Project/Area Number |
26640061
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory animal science
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | アフリカメダカ |
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| Outline of Final Research Achievements |
In this research project, we found that Africa medaka (short-lived vertebrate) showed Parkinson-like pathology in age-dependent manner. This phenotype was not caused by genetic manipulation or toxin exposure but by aging. This medaka showed neurodegeneration and progression of alpha-synuclein pathology in older stage. This phenotype is very similar to human Parkinson disease phenotype.
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| Free Research Field |
神経内科学
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