Screening for regulatory factors of iPS cell generation using haploid ES cells

2015 Fiscal Year Final Research Report

• Project/Area Number: 26640062
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Laboratory animal science
• Research Institution: Nara Medical University
• Principal Investigator: Horie Kyoji 奈良県立医科大学, 医学部, 教授 (30333446)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 遺伝学 / ゲノム / 再生医学 / バイオテクノロジー / 発生・分化

Outline of Final Research Achievements

We have established an experimental system to efficiently elucidate gene functions by introducing gene mutations in a genome-wide manner. We utilized mouse ES cells as a model system. ES cells and iPS cells are drawing attentions as a promising tool for regenerative medicine. Another useful aspect of ES cells and iPS cells is that they provide excellent experimental protocols for the investigation of cell lineage determination. The method established in the present study will be applicable in various fields of life science.

Free Research Field

分子生物学