What is the authentic tumor initiating cells in healthy mice?

2015 Fiscal Year Final Research Report

• Project/Area Number: 26640066
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology
• Research Institution: Hokkaido University
• Principal Investigator: Wada Haruka 北海道大学, 遺伝子病制御研究所, 講師 (70392181)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 造腫瘍細胞 / がん幹細胞 / 免疫 / がん細胞の特性

Outline of Final Research Achievements

Many kinds of tumor cells include in tumor tissue. Recent research using immune-deficient mice revealed that tumor initiating cells (TIC) only have a potential to form tumor tissue. However, we proposed that we need to identify TIC in immune-healthy body. Such TIC is authentic TIC which we should realistically focused on. We found that TIC secretes TIC-associated immune cell factors (TICIF). TICIF deficient TIC no longer initiated tumor in immune-healthy body but they nevertheless formed tumor in immune-deficient mice. These results indicated that TIC secreting tumor cells are authentic tumor cells in immune-healthy body.

Free Research Field

腫瘍生物学