Characterization the role of nuclear pore proteins in mitosis

2015 Fiscal Year Final Research Report

• Project/Area Number: 26640071
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology
• Research Institution: Kanazawa University
• Principal Investigator: Wong Richard 金沢大学, 新学術創成研究機構, 教授 (30464035)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 核膜孔複合体 / 細胞周期 / Tpr / Nup62 / Nup358 / 中心体

Outline of Final Research Achievements

Nuclear pore complexes (NPC) are large protein channels that act as the sole mediators of molecular exchange between the nucleus and the cytoplasm of eukaryotic cells. Besides its function in controlling nucleocytoplasmic transport, the NPC and its components have been found to exert many transport independent functions. One of the most studied ones are the mitotic roles of nucleoporins. We and others discovered that NPCs disassemble during mitotic nuclear envelope breakdown, many soluble nucleoporins have been found to relocate to kinetochores, mitotic spindles and centrosomes. In this project, we are investigating the NPC proteins at the centrosomes. We have published 4 papers (IF5) or above.

Free Research Field

総合生物