Development of diagnostic system of mutations in breast cancer by using primary spheroid cells derived from patients

2015 Fiscal Year Final Research Report

• Project/Area Number: 26640072
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology
• Research Institution: Kanazawa University
• Principal Investigator: Gotoh Noriko 金沢大学, がん進展制御研究所, 教授 (10251448)
• Co-Investigator(Kenkyū-buntansha): NAKATA Asuka 金沢大学, がん進展制御研究所, 助教 (70597921) ; SUZUKI Yutaka 東京大学, 新領域創成科学研究科, 教授 (40323646)
• Co-Investigator(Renkei-kenkyūsha): YOSHIDA Ryo 統計数理研究所, モデリング研究系データ同化研究開発センター, 准教授 (70401263) ; TOJO Arinobu 東京大学, 医科学研究所, 教授 (00211681) ; OGAWA Toshihisa 東京大学, 附属病院, 准教授 (80224111) ; INOKUCHI Masashi 金沢大学, 附属病院, 助教 (90401918)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 幹細胞

Outline of Final Research Achievements

We performed exome sequence and RNA sequence by using primary cultured cells derived from tumor tissues of breast cancer patients. We analyzed luminal type A, luminal type B and triple negative type breast cancer tissues. We found several novel molecular targets in breast cancer stem-like cells. Functional analysis of these molecules, we identified promising molecular targets of breast cancer stem-like cells.

Free Research Field

分子腫瘍学