Dissecting the mechanism of cell competition by using novel model system

2015 Fiscal Year Final Research Report

• Project/Area Number: 26640077
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology
• Research Institution: Kyoto University
• Principal Investigator: Ohsawa Shizue 京都大学, 生命科学研究科, 准教授 (80515065)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 細胞競合 / Wiingless

Outline of Final Research Achievements

There are growing evidence showing that “Cell Competition”, a struggle for existence in multicellular communities, positively and negatively regulates cancer development and progression. However, the molecular mechanism of cell competition is still unclear. In this study, by using Gal4/UAS system in Drosophila imaginal epithelia, we established a novel model system for cell competition, in which cell competition occurs continuously, enabling us to detect cell competition more easily. We found by using this model system that Wingless signaling (a mammalian Wnt homolog) regulate cell competition triggered by differential expression level of ribosomal proteins.

Free Research Field

発生遺伝学