2016 Fiscal Year Final Research Report
Analysis of molecular mechanisms involved in the conversion of iPSs into cancer stem cells
| Project/Area Number |
26640079
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Okayama University |
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Principal Investigator |
Seno Masaharu 岡山大学, 自然科学研究科, 教授 (90243493)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | iPS細胞 |
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| Outline of Final Research Achievements |
During the process of cancer stem cells (CSC) generation from induced pluripotent stem cells (iPS), we investigated which signaling pathways were involved in the CSC generation. By screening from various signal inhibitors, we found that the GSK3beta and MEK inhibition promoted CSC generation. In addition, we performed the comprehensive gene expression and epigenetic analysis to find out the intracellular change(s), and nominated candidate genes that might be contributing to the CSC generation.
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| Free Research Field |
総合生物
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