Adsorption behaviors of exosomes on surfaces of various properties

2015 Fiscal Year Final Research Report

• Project/Area Number: 26640094
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Tumor diagnostics
• Research Institution: Japanese Foundation for Cancer Research
• Principal Investigator: Matsumura Sachiko 公益財団法人がん研究会, その他部局等, 特任研究員 (90414052)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: エクソソーム / 癌 / ナノ粒子 / 走査プローブ顕微鏡 / 表面科学 / 細胞外ベシクル

Outline of Final Research Achievements

Extracellular vesicles including exosomes are recognized as novel intercellular communication vehicles, and it has been revealed that they play significant roles in various diseases processes. Therefore, they are appreciated as a potential biomarker or target for the diagnosis and therapy. However, the purification and characterization of exosomes is still insufficient. In this study, adsorption behaviors of exosomes were examined on surfaces of various properties using atomic force microscopy. Adsorption behaviors of exosomes were different depending on the surfaces properties and cell lines, indicating that the difference in adsorption on the surfaces can be available for characterization of exosomes.

Free Research Field

生体関連化学、ナノバイオ