2015 Fiscal Year Final Research Report
A fundamental study to develop novel targeted drug delivery systems for multiple myeloma therapy
| Project/Area Number |
26640101
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor therapeutics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Imai Kohzoh 東京大学, 医科学研究所, 特任研究員 (60117603)
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| Co-Investigator(Kenkyū-buntansha) |
YASUI Hiroshi 東京大学, 医科学研究所, 特任准教授 (40448593)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 多発性骨髄腫 / Drug Delivery System / 橋渡し研究 / 骨髄微小環境 / 免疫細胞 |
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| Outline of Final Research Achievements |
In the present study, we developed novel therapeutics using drug delivery systems (DDS) for multiple myeloma (MM) treatment. Since MM cells closely interact with their bone marrow microenvironment, thereby contributing to their pathophysiology, we selected polymeric micelles suitable to MM cells and their microenvironment, as well as ligand molecules to be integrated with the micelles. In addition, we developed a novel DDS to induce anti-MM activities by recruiting immune cells to tumor cells. Thus, a fundamental system to develop novel therapeutics using DDS suitable for MM and its microenvironment was established in this study.
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| Free Research Field |
腫瘍学
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