2015 Fiscal Year Final Research Report
Search for the origin of H. pylori
| Project/Area Number |
26640114
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Genome biology
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI RUMIKO 大分大学, 医学部, 助教 (70599092)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | ヘリコバクター属 / ヘリコバクター・ピロリ / 次世代シーケンサー / 起源 |
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| Outline of Final Research Achievements |
The variable regions of 16S rRNA genes were determined by next generation sequencing from the formalin-fixed paraffin-embedded gastric tissues from the reindeer and other animals. These sequences were highly identity with H. pylori and H. acinonychis. Also we determined the whole genome sequences of Alaskan H. pylori strains. Moreover, the genome structure comparison analysis indicated that its structure was partially shared with that of H. acinonychis. Phylogenetic analysis based on these 724 homologues genes shown that Alaskan strains clustered within own lineage independently. Our results suggested that the possibility to find an origin of H. pylori infection to human from the herbivorous animals. Further genetic analysis of H. acinonychis will be successful to verify our hypothesis.
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| Free Research Field |
消化管感染症
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