2015 Fiscal Year Final Research Report
Analysis of somatic alteration of copy number variation in cancer as a new instability of cancer
| Project/Area Number |
26640121
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical genome science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | コピー数多型 / 乳がん |
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| Outline of Final Research Achievements |
Somatic alterations of copy number variation (CNV), a new DNA polymorphism, were analyzed in 52 tumors, including breast, tongue and bladder cancer and cholangiocarcinoma, using CNV-specific arrays in order to elucidate their molecular feature, pathological significance and resulted genetic alterations. We demonstrated that somatic alterations of CNV in the fragments of less than 10kb occurred independently of those in the fragments of more than 1Mb and defined as CNV instability. CNV instability was observed in 10-20% of 4 cancers, especially those in advanced stages. Genetic alterations caused by somatic CNV alterations were also examined in breast cancers and a number of candidate genes were identified. Analysis of somatic CNV alteration would provide a novel approach to identify critical genes as well as a new pathway in the development and progression of human cancer.
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| Free Research Field |
分子腫瘍学
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