2015 Fiscal Year Final Research Report
Physiological role of Ufm1 system
| Project/Area Number |
26650012
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Molecular biology
|
|---|
| Research Institution | Niigata University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | タンパク質修飾 / Ufm1 / Uba5 / ノックアウトマウス / 遺伝性発達障害 |
|---|
| Outline of Final Research Achievements |
1.We identified UBA5 as a causative gene for a hereditary developmental disease. 2.We generated knock-in mice harboring the disease-related Uba5 mutation. 3.We developed an experiment system that we can easily detect Ufm1-conjugated proteins, and we identified several novel targets for Ufm1 using this system.
|
| Free Research Field |
分子細胞生物学、生化学
|
