2015 Fiscal Year Final Research Report
Role for apoptosis-dependent phagocytosis in cancer prevention
| Project/Area Number |
26650030
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 癌 / アポトーシス / 貪食 / ショウジョウバエ / チェックポイント |
|---|
| Outline of Final Research Achievements |
During cell division cycle, the check point system scrutinizes cells if they possess defects. Cells found to bear defects get off the cycle for repair, and those not repaired completely undergo apoptosis-dependent phagocytosis. Although the requirement of apoptosis has been shown, that of phagocytosis remains to be known. In a model system using fruit fly Drosophila, cancer develops when both check point and apoptosis are inhibited. We aimed at examining the occurrence of cancer when phagocytosis, not apoptosis, is inhibited together with check point. We succeeded in establishing a cancer model spending first 1 and half years and started to generate animals with defects in check point and phagocytosis. However, we were unable to achieve it before the period of time for this research ended. Therefore, we could not accomplish the purpose.
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| Free Research Field |
生化学
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