2015 Fiscal Year Final Research Report
Investigation of validity of membrane theory
| Project/Area Number |
26650032
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | Gifu University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 膜電位 / Goldman-Hodgkin-Katzの式 / Donnan理論 / 吸着理論 |
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| Outline of Final Research Achievements |
The potential between two electrolytic solutions separated by a membrane impermeable to ions was measured and. From the physiological point of view, a nonzero membrane potential or action potential cannot be observed across the impermeable membrane. However, a nonzero membrane potential including action potential-like potential was clearly observed. Those observations gave rise to a doubt concerning the validity of currently accepted generation mechanism of membrane potential and action potential of cell. As an alternative theory, we found that the long-forgotten Ling's adsorption theory was the most plausible theory. It suggests that the membrane potential and action potential of a living cell is due to the adsorption of mobile ions onto the adsorption site of cell. Consequently, it was found that Ling's adsorption theory was in full harmony with the experimental facts.
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| Free Research Field |
電気化学 高分子材料工学
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