Development of a drug delivery system equipped with timer

2015 Fiscal Year Final Research Report

• Project/Area Number: 26650054
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biophysics
• Research Institution: Institute for Molecular Science
• Principal Investigator: AKIYAMA Shuji 分子科学研究所, 協奏分子システム研究センター, 教授 (50391842)
• Co-Investigator(Kenkyū-buntansha): MUKAIYAMA Atsushi 分子科学研究所, 協奏分子システム研究センター, 助教 (80647446)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 物質輸送

Outline of Final Research Achievements

This research project aims at developing a drug delivery system with biological clock. We found that encapsulation of the clock proteins from cyanobacteria into ready-made liposome resulted in loss of their function, possibly due to unfavorable adsorption with membrane of the liposome. We are trying to establish the protocol to encapsulate as intact clock proteins by using micro-meter-sized giant liposomes.

Free Research Field

生物物理学