Analysis of evolution of mitochondrial transport regulation system from endosymbiotic bacteria Wolbachia

2015 Fiscal Year Final Research Report

• Project/Area Number: 26650061
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Cell biology
• Research Institution: Kyushu Institute of Technology
• Principal Investigator: Kitada Sakae 九州工業大学, 情報工学研究院, 准教授 (20284482)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: ミトコンドリア / ウォルバキア / ボルバキア / 進化 / 共生

Outline of Final Research Achievements

There are two unknown events in mitochondrial symbiotic evolution. One is most gene transfer of symbiont genome to host chromosome. The other is a dynamic system that the transferred gene products, mitochondrial proteins, import into mitochondria. In this research, we focused later evolutional event in mitochondria. As model proteins from eukaryote and endosymbiotic bacteria Wolbachia, we tried to investigate and propos novel mitochondrial evolution using bioinformatics and experimental analyses. As the results, we found Wolbachia genes which could be homologous to genes of mitochondrial transport regulation system. Under cell culture experiment, we constructed mammalian cells system infected Wolbachia.

Free Research Field

細胞生物学