Physiological significance of the inter-chromosomal glue that loosely clusters mitotic chromosomes

2016 Fiscal Year Final Research Report

• Project/Area Number: 26650070
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Cell biology
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Takagi Masatoshi 国立研究開発法人理化学研究所, 今本細胞核機能研究室, 専任研究員 (60324779)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 分裂期染色体 / Ki-67 / AID / 染色体安定性 / 染色体間グルー / 微小核

Outline of Final Research Achievements

Observation of chromosome dynamics at the early stage of mitosis in human cultured cells revealed that most chromosomes behave as a gently consolidated group. In this study, we investigated the possibility that the Ki-67 antigen might function as "inter-chromosomal glue" which promotes the behavior of whole mitotic chromosomes in a group. In addition, we proposed a possibility that the inter-chromosomal glue might contribute for the maintenance of chromosome stability via raising the probability that all segregated chromosomes in anaphase are stored in one nucleus in telophase.

Free Research Field

細胞生物学