2016 Fiscal Year Final Research Report
Microbial degradation of bioactive substance from turmeric
| Project/Area Number |
26660055
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied microbiology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 微生物 / 酵素 |
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| Outline of Final Research Achievements |
While enzymes involved in the metabolism of curcumin, a yellow pigment, derived from the rhizomes of a plant (Curcuma longa Linn) were unknown, we previously purified curcumin-converting enzyme from E. coli and characterized. Here, we isolated microorganisms that degrade a curcumin from soil.
From the microorganism exhibiting the highest activity among newly isolated microorganisms, we identified a novel metabolite of curcumin, and found that the metabolite is different from those from E. coli. Based upon the physiological characteristics, the isolated microorganism was identified. We succeeded in the purification of the curcumin-converting enzyme and identification of its enzymatic reaction product.
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| Free Research Field |
応用微生物学
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