2015 Fiscal Year Final Research Report
Nutritional and physiological analysis of derivative of hydroxyproline
| Project/Area Number |
26660104
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Utsunomiya University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NIHEI Kenichi 宇都宮大学, 農学部, 准教授 (10307209)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | コラーゲン |
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| Outline of Final Research Achievements |
In this study, we have analyzed the physiological function of derivatives of hydroxyproline, a major amino acid in collagen. We have prepared di-hydroxyproline, which is synthesized by hydration of hydroxyproline. We also prepared derivative of tri-peptide, which is synthesized by the dehydration of hydroxyprolyl-glycyl-proline, whose amino acid sequence is most frequently appeared in type 1 collagen. We carried out biochemical evaluation of these compounds especially with respect to anti-oxidative activity and toxicity to cancer cells. The results have shown that di-hydroxyproline have significant anti-oxidative activity which is evident by suppressing oxidation of linoleic acid. Also, novel tri-peptide have shown anti-oxidative activity. Together, we this study have shown the novel anti-oxidative reagent and potential diagnostic marker to fibrotic diseases.
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| Free Research Field |
生物化学
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