2016 Fiscal Year Final Research Report
Physiological significance of enterophagocyte non-enzymatic intracellular digestion of indigestible food components
| Project/Area Number |
26660109
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 難消化性食品成分 / 非酵素的細胞内消化 / 腸管食細胞 |
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| Outline of Final Research Achievements |
Food contains a variety of indigestible components such as cell walls of plants and microbes. Such indigestible components are called dietary fiber in general, and many researches have been conducted in terms of effects via intestinal bacterial flora on the large bowel physiology. However, no many researches have been done from a viewpoint of intestinal uptake of such indigestible components. In the present study, Uptake, intracellular degradation and release of some indigestible components such as curdlan, zymosan, and Bifidobacteria were investigated using a macrophage cell line, and it was demonstrated that such indigestible components taken up by the cell were degraded non-enzymatically and that the degraded fragments were release again and stimulated enteric immune cells in a paracrine manner.
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| Free Research Field |
食品科学
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