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2015 Fiscal Year Final Research Report

The development of a novel sensitizing radiation therapy in conjunction with microbubbles and ultrasound exposure

Research Project

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Project/Area Number 26660233
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Veterinary medical science
Research InstitutionHokkaido University

Principal Investigator

TAKIGUCHI Mitsuyoshi  北海道大学, (連合)獣医学研究科, 教授 (70261336)

Co-Investigator(Kenkyū-buntansha) SASAKI Noboru  北海道大学, 大学院獣医学研究科, 助教 (00754532)
Project Period (FY) 2014-04-01 – 2016-03-31
Keywords獣医学 / 超音波 / マイクロバブル / 増感放射線療法 / ソノポレーション
Outline of Final Research Achievements

The purpose of this study is to clarify the sensitizing effect of irradiation-induced apoptosis after ultrasound exposure in the presence of microbubbles. Mouse sequemous cell carcinoma cell was irradiated right after the ultrasonic exposure with microbubbles resulted in sensitizing effect of 1.1. After considering optimal irradiation timing in the light of the effect of cell cycle variation of ultrasound exposure, it was suggested that 9 hours after the ultrasound exposure was suitable. However, the sensitizing effect of irradiation-induced apoptosis remained 1.1. Further study is needed using 3-dimensional cell culture system.

Free Research Field

獣医内科学

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Published: 2017-05-10  

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