Development of low invasive radio-induced hyperthermia against the deep part tumor

2015 Fiscal Year Final Research Report

• Project/Area Number: 26660240
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Veterinary medical science
• Research Institution: Tottori University
• Principal Investigator: OKAMOTO Yoshiharu 鳥取大学, 農学部, 教授 (50194410)
• Co-Investigator(Kenkyū-buntansha): TAMURA yutaka 千葉大学, 大学院医学研究院, 准教授 (50263174) ; AWAZU Kunio 大阪大学, 大学院工学研究科, 教授 (30324817) ; ASANUMA Taketoshi 宮崎大学, 農学部, 教授 (40332473) ; SUGIYAMA Masahiko 鳥取大学, 農学部, 准教授 (00432609)
• Co-Investigator(Renkei-kenkyūsha): OSAKI Tomohiro 鳥取大学, 農学部, 准教授 (40431332) ; TSUKA Takeshi 鳥取大学, 農学部, 准教授 (30432610) ; AZUMA Kazuo 鳥取大学, 農学部, 准教授 (50721841)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: がん / 温熱療法 / ラジオ波 / 胎児 / 自然発症動物 / 犬猫

Outline of Final Research Achievements

In the present study, we recognized onchothermia heat selectively tumor tissue. In vivo study using pregnant rat, it was found that onchothermia did not have effect on organogesis of the brain. In addition, it was found that onchothermia induced apoptosis in mouse model. Furthermore, it was found that onchothermia did not decrease the volume of the animal spontaneous tumors. However, by combination of low dose chemotherapy, this therapy became to be effective for the tumors.

Free Research Field

獣医外科学