Identification of genes causing canine breed differences in disease susceptibility by a new analysis method

2014 Fiscal Year Final Research Report

• Project/Area Number: 26660244
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Veterinary medical science
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: MOMOZAWA Yukihide 独立行政法人理化学研究所, 統合生命医科学研究センター, 研究員 (40708583)
• Project Period (FY): 2014-04-01 – 2015-03-31
• Keywords: イヌ / ゲノム / 疾患 / 犬種差 / SNP / 統計

Outline of Final Research Achievements

It is very important for veterinary medicine to identify genetic variants associated with disease risk. For this purpose, we developed a new method focusing on breed differences in disease susceptibility. We also collected frequency information of genetic variants over canine whole genome in 40 breeds and disease susceptibility of each breed for 80 diseases. Finally, we applied the new method to these dataset and newly identified eight genome wide significant associations between genetic variants and disease susceptibility.

Free Research Field

動物遺伝学