The relationship between skeletal muscle fiber type and muscle satellite cells

2015 Fiscal Year Final Research Report

• Project/Area Number: 26660251
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Integrative animal science
• Research Institution: Kyushu University
• Principal Investigator: MIZUNOYA WATARU 九州大学, (連合)農学研究科(研究院), 助教 (20404056)
• Co-Investigator(Kenkyū-buntansha): TATSUMI RYUICHI 九州大学, 大学院農学研究院, 准教授 (40250493)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 骨格筋 / 筋線維タイプ / 筋衛星細胞 / Cre/loxpシステム / 運動トレーニング / タモキシフェン / マウス

Outline of Final Research Achievements

Composition of skeletal muscle fiber types affects meat quality such as nutritional and physicochemical properties. Here, we tested whether muscle satellite cells could affect muscle fiber type composition. We completed the introduction of the transgenic mouse strain which enables muscle satellite cells ablation induced by Tamoxifen injection. We also found the muscle fiber type composition was altered by muscle injury and regeneration, suggesting muscle satellite cells could affect the muscle fiber type composition after regeneration.

Free Research Field

筋細胞生物学・食肉科学