Molecular identity of large protein complexes with potential roles in cooperative regulation of different phases in plant cell cycle

2015 Fiscal Year Final Research Report

• Project/Area Number: 26660290
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied molecular and cellular biology
• Research Institution: Nagoya University
• Principal Investigator: Ito Masaki 名古屋大学, 生命農学研究科, 准教授 (10242851)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 転写因子複合体 / 細胞周期 / Myb転写因子 / E2F / シロイヌナズナ / DREAM複合体

Outline of Final Research Achievements

Proliferation of plant cells should be regulated spatially and temporally during plant organ growth. This regulation largely relies on the proper transcriptional regulation of the cohort of genes with cell cycle-related functions. Among them, two main classes of genes, G1/S- and G2/M-specific genes, are known to be regulated by families of transcription factors, called E2F and MYB3R, respectively. In this study, we first showed that MYB3R and E2F family proteins are present together in the same multi-protein complex in plants, which may be evolutionarily related to the protein complex, known as DREAM complex in animals such as human, fly, and worm. Unlike other organisms, plants specifically express multiple DREAM-like protein complexes that contain different members from E2F and MYB3R families and probably have distinct functions in the cell cycle.

Free Research Field

植物生理学