2015 Fiscal Year Final Research Report
Asymmetric induction by using carbocations as a reactive species
| Project/Area Number |
26670001
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KITAMURA Masanori 金沢大学, 医薬保健研究域薬学系, 准教授 (80453835)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | Asymmetric induction / Carbocations |
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| Outline of Final Research Achievements |
Asymmetric induction utilizing highly reactive carbocations is an attractive and challenging theme. We hypothesized that if an optically active asymmetric ether coordinates to a prochiral carbocation in a face-selective manner, stereoselectivity can be achieved in alkylation of nucleophiles. As a result, we succeeded in development of various reagents that enable to generate carbocationic species available for the study of asymmetric induction. In addition, in a Friedel-Crafts reaction using phenethylcationic species in the presence of an asymmetric ether, we observed asymmetric induction even though the selectivity was insufficient.
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| Free Research Field |
有機化学
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