2015 Fiscal Year Final Research Report
Asymmetric C-H oxidation with a designed self-assembling catalyst
| Project/Area Number |
26670006
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 酸化 / 不斉合成 / イオン対 / マンガン / ラクトン |
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| Outline of Final Research Achievements |
In this project, we planned to use a concept of chiral ion-pairing to construct unique chiral environment around an oxidation catalyst toward the development of selective C-H oxidation transformations. First, iron or manganese-N5 complexes having chiral counter anions such as chiral phosphates and sulfonates were synthesized. Probably due to slow exchange rate of the counter anion, oxidation was retarded considerably. In contrast, CH oxidation proceeded in using a N4 ligand. When alkane with a carboxylic acid as a directing group was employed, the oxidation occurred at the benzylic position in good yield, affording the corresponding lactones with moderate enantioselectivity.
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| Free Research Field |
有機化学
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