2015 Fiscal Year Final Research Report
Research on Asymmetric Catalysis Based on Design and Synthesis of New Chiral Pincer-Type NHC Ligand
| Project/Area Number |
26670007
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Waseda University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 有機化学 / 不斉触媒反応 / NHC配位子 |
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| Outline of Final Research Achievements |
We have established a synthetic method for the bisoxazoline-NHC-Ag(I) complex via concomitant formation of oxazolines and NHC using silver oxide, and the bisoxazoline-NHC-Ag(I) complex were converted to the corresponding pincer-type NHC-metal complexes. The NHC-Cr(III) complex showed no catalytic activity, but the dicationic NHC-Pt(II) complex catalyzed cycloisomerization of a 1,5-ene-yne albeit with low enantioselectivity. We have successfully synthesized a binaphthyl-fused imidazolylidene-AuCl complex and have found that the corresponding cationic complex catalyzes enantioselective cyclization of an ene-yne to afford quantitatively the product with 78% ee. Synthesis of the corresponding pincer-type binaphthyl-fused NHC ligands is now investigation.
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| Free Research Field |
医歯薬学
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