Development of a novel Cherenkov imaging method for evaluating the effect of internal radiation therapy

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670011
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Physical pharmacy
• Research Institution: Kyoto University
• Principal Investigator: Hideo Saji 京都大学, 薬学研究科(研究院), 教授 (40115853)
• Co-Investigator(Kenkyū-buntansha): KIMURA Hiroyuki 京都薬科大学, 薬学部, 准教授 (50437240) ; TEMMA Takashi 国立研究開発法人国立循環器病研究センター, 室長 (90378787)
• Co-Investigator(Renkei-kenkyūsha): ONO Masahiro 京都大学, 薬学研究科(研究院), 准教授 (80336180) ; SANO Kohei 京都大学, 医学(系)研究科(研究院), 助教 (00546476)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: イメージング / チェレンコフ光

Outline of Final Research Achievements

The purpose of this study is to establish a novel in vivo Cherenkov imaging methods for evaluating the effect of internal radiation therapy. Anti-EGFR monoclonal antibody was labeled with Cu-64 and Y-90, and in vivo Cherenkov imaging was performed in tumor-bearing mice. In vivo biodistribution of radioactivity was detected by Cherenkov imaging for both probes, but for tumor imaging, antibody labeled with Y-90, which has long half-life compared to Cu-64, clearly visualized tumor tissues. Signal intensity in each tissue was correlated with in vivo biodistribution of radioactivity, therefore, Cherenkov imaging has a potential for predicting biodistribution of 90Y-labeled antibody for evaluating the effect of internal radiation therapy.

Free Research Field

医歯薬学