2015 Fiscal Year Final Research Report
Development of DDS applicable for immune therapy by using self-assembling RNA sponge particle
| Project/Area Number |
26670013
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NISHIKAWA Makiya 京都大学, 大学院薬学研究科, 准教授 (40273437)
TAKAHASHI Yuki 京都大学, 大学院薬学研究科, 助教 (00547870)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | ドラッグデリバリー / アジュバント / ワクチン / TLR3 |
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| Outline of Final Research Achievements |
In the present study, we selected magnesium pyrophosphate particle (MgPP), and loaded polyI:C, an immunostimulatory nucleic acid, to MgPP to develop an adjuvant system. PolyI:C was loaded to MgPP by adding polyI:C to the MgPP preparation step. Loading polyI:C to MgPP enhanced the uptake of polyI:C by immune cells and following cytokine release. Moreover, the addition of polyI:C-loaded MgPP containing an antigen to dendritic cells resulted in improved antigen presentation.
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| Free Research Field |
生物薬剤学
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