Improvement of obesity by redox regulation

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670017
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Physical pharmacy
• Research Institution: Kyushu University
• Principal Investigator: Yamada Ken-ichi 九州大学, 薬学研究科(研究院), 准教授 (60346806)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 薬学 / ストレス

Outline of Final Research Achievements

Continuous energy conversion is controlled by reduction and oxidation (redox) processes. NAD+ and NADH represent an important redox couple in energy metabolism. 4-Hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPOL) is a redox-cycling nitroxide that promotes the scavenging of several reactive oxygen species (ROS) and is reduced to hydroxylamine by NADH. TEMPOL is also involved in NAD+ production in the ascorbic acid and glutathione redox cycle. We utilized the chemical properties of TEMPOL to investigate the effects of antioxidants and NAD+/NADH modulators on the metabolic imbalance in obese mice. Increases in the NAD+/NADH ratio by TEMPOL ameliorated the metabolic imbalance. These findings provide novel insights into redox regulation in obesity.

Free Research Field

生物物理化学