2015 Fiscal Year Final Research Report
Molecular mechanisms of Nuclear IkappaB family proteins control immune maturation.
| Project/Area Number |
26670019
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Gifu University |
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Principal Investigator |
MaruYama Takashi 岐阜大学, 医学(系)研究科(研究院), 助教 (10622524)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | IkB-zeta / IkBNS / T細胞 / 胸腺 / 成熟 |
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| Outline of Final Research Achievements |
This study focus on T cells maturation in the thymus and the role of nuclear IkB-zeta and IkB-NS.
T cell specific IkB-zeta deficient mice show less maturation rate of T cells, because more apoptotic gene expression. On the other hands, T cell maturation rate from IkBNS deficient mice was comparable compared with control mice. Interestingly, T cell specific IkBNS over-expressing mice shows inflammatory phenotype and have problems of T cell maturation.Interestingly, transcriptional activity and mechanisms of IkB-zeta and IkBNS is difference and do not compete against target genes, including IFN-gamma, IL-17A and ELAM-1.
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| Free Research Field |
免疫学
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