2015 Fiscal Year Final Research Report
Screening for proteasome-activating compounds that could cure neurodegenerative diseases
Project/Area Number |
26670022
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Biological pharmacy
|
Research Institution | The University of Tokyo |
Principal Investigator |
Murata Shigeo 東京大学, 薬学研究科(研究院), 教授 (20344070)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Keywords | プロテアソーム / 変性タンパク質 / タンパク質分解 / 神経変性疾患 |
Outline of Final Research Achievements |
To develop a drug that can cure neurodegenerative diseases, we screened a chemical library for small molecules that activate proteasomes and promote degradation of misfolded proteins observed in neurodegenerative diseases such as SOD1, tau, and α-synuclein, and identified several promising compounds.
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Free Research Field |
細胞内タンパク質分解
|