2015 Fiscal Year Final Research Report
Genes that enable high-efficiency gene disruption in human cells
| Project/Area Number |
26670031
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Yokohama City University |
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Principal Investigator |
Adachi Noritaka 横浜市立大学, 生命ナノシステム科学研究科(八景キャンパス), 教授 (30264675)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | ゲノム改変 / ジーンターゲティング / Nalm-6 |
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| Outline of Final Research Achievements |
In this research project, we have identified several human genes that increase the efficiency of gene targeting by homologous recombination. We have shown for the first time that an enzyme with cytidine deaminase activity can enhance gene targeting in NHEJ-null cells.
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| Free Research Field |
分子生物学
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