2015 Fiscal Year Final Research Report
Development of lead commands for new anti-infective agents
| Project/Area Number |
26670043
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Natural medicines
|
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 抗菌薬 / 化合物ライブラリー / カイコ / 作用機序解析 |
|---|
| Outline of Final Research Achievements |
We evaluated antimicrobial activity and mechanistic analysis of the compounds which identified by therapeutic effectiveness on silkworm infection model. These compounds showed antimicrobial activity against Staphylococci, and one of compound showed prolonged proliferation activity on mouse systemic infection model. This compound is implied to have a novel mechanism. These results suggest that silkworm infection model is useful model to identity therapeutically effective antimicrobial compounds from synthetic compounds library.
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| Free Research Field |
微生物学
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