2015 Fiscal Year Final Research Report
Search for specific inhibitors of the ubiquitin-conjugating enzyme E2
| Project/Area Number |
26670047
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Natural medicines
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YOKOSAWA Hideyoshi 愛知学院大学, 薬学部, 教授 (90012765)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | ユビキチン結合酵素E2 / UBE2S / Ubc13 / ユビキチン修飾系 |
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| Outline of Final Research Achievements |
Ubiquitin chain in different topologies related to distinct functional consequences, including protein degradation, NF-κB activation, and DNA repair. The ubiquitin chain assembly is mostly promoted by E2s, but the linkage specificity by E2s is hardly understood. In this study, we searched for UBE2S inhibitors from natural sources as bio-probes to study the mechanisms of K11-ubiquitin chain elongation. We established the in-house screening system for UBE2S inhibitors and found the several positive extracts from our library of extracts of natural sources. The isolation and structure determination of the inhibitors are in progress.
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| Free Research Field |
天然物化学
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