Screening of anti-tuberculosis substances produced by microorganism

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670049
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Natural medicines
• Research Institution: Kitasato University
• Principal Investigator: Miura Hiromi 北里大学, 感染制御科学府, 助教 (20462252)
• Co-Investigator(Kenkyū-buntansha): MATSUMOTO Atsuko 北里大学, 感染制御科学府, 講師 (20300759) ; NAKASHIMA Takuji 北里大学, 北里生命科学研究所, 特任准教授 (40526216)
• Co-Investigator(Renkei-kenkyūsha): TAKAHASHI Yōko 北里大学, 感染制御科学府, 研究員 (80197186) ; SHIOMI Kazuro 北里大学, 感染制御科学府, 教授 (40235502) ; IWATSUKI Masato 北里大学, 感染制御科学府, 講師 (70353464)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 抗結核菌物質 / 放線菌 / 微生物培養抽出液 / 二次代謝産物

Outline of Final Research Achievements

To discover anti-tuberclosis drugs with a new mechanisms of action, we invented simple screening system that is targeted to biosynthesis pathway of diaminopimelate (DAP). We screened approximately 9,600 culture broths of actinomycete and fungi. As a result, we found anti-mycobacterium substance produced by Streptomyces sp. K12-0214. This substance is water-soluble, irreversibly inactivated under basic condition. Anti-microbial spectrum of this material was different from that of existing drug isoniadide and rifampicin.

Free Research Field

応用微生物学