Development of anti-HIV agents targeting weak points of viral replication mechanism

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670053
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Drug development chemistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Tamamura Hirokazu 東京医科歯科大学, 生体材料工学研究所, 教授 (80217182)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 抗HIV薬 / 多量体形成 / カプシドタンパク質 / エンベロープタンパク質gp41 / ペプチドライブラリー / 治療標的

Outline of Final Research Achievements

In this study we tried to develop novel anti-HIV agents based on our new concept. HIV proteins have some structures required for function maintenance involving oligomerization, which might be difficult to mutate. It is important to search these targets in the development of drug seeds. Capsid proteins and an envelope protein gp41 relevant to oligomer formation might have conformationally weak regions against mutation. We tried to search these regions. In consideration of these weal points as our targets, anti-HIV leads were found using peptide libraries. Finally, treatment targets were elucidated and breakthrough for creation of anti-HIV agents was accomplished.

Free Research Field

創薬化学