Development of anti-IL-33 agent and application for prevention of early allergic disease

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670057
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Drug development chemistry
• Research Institution: Kumamoto University
• Principal Investigator: Shoji Shozo 熊本大学, 大学院生命科学研究部(薬), 名誉教授 (60040317)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: IL-33

Outline of Final Research Achievements

IL-33, a member of IL-1 family, is deeply associated with allergic reactions. In this study, we explored the anti-IL-33 agents. We established an in vitro assay system using KU812 cells that are known as immature human basophilic cell line to investigate the anti-IL-33 agents. Reported crystallographic structure of complex of IL-33 and the receptor ST2L was referred to select already known compounds or to synthesized novel compounds for the evaluation. As a result, two novel compounds, named Fi-10 and Fi-11, interestingly showed highest anti-IL-33 activity in the examined compounds in this study. It was suggested that the two compounds directly act to IL-33 to inhibit the activity. Further optimization of the chemical structure based on our results should be required to develop highly specific anti-IL-33 agents in the future.

Free Research Field

医歯薬学