2015 Fiscal Year Final Research Report
Development of fluorescence imaging of virus infection using a new sialidase probe
| Project/Area Number |
26670064
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
IKEDA Kiyoshi 広島国際大学, 薬学部, 教授 (40168125)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | シアリダーゼ / 蛍光イメージング / インフルエンザウイルス / パラインフルエンザウイルス / ノイラミニダーゼ / ヘマグルチニン-ノイラミニダーゼ / ウイルス単離 / 薬剤耐性 |
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| Outline of Final Research Achievements |
Influenza A and B virus and some parainfluenza viruses and their infected cells express an enzyme “sialidase” on their surface membrane. We established easy and rapid method for fluorescent visualization of infected cells by development of fluorescent imaging probe of sialidase activity. Virus strain was directly isolated from a population of fluorescent infected cells with no need of fixation.
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| Free Research Field |
医歯薬学
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