Indole analog mitochonic acid-5 (MA-5) has novel therapeutic effects on kidney injury

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670070
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Tohoku University
• Principal Investigator: ABE Takaaki 東北大学, 医工学研究科, 教授 (80292209)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: CKD / インドール / MA=5 / 虚血再灌流

Outline of Final Research Achievements

Chronic kidney disease (CKD) is a global health problem that carries a substantial risk for cardiovascular disease and death.
We recently found that several indole-derivatives increased ATP levels in cells by screening of 41 newly synthesized indole derivatives. Among those compounds, we focused on the most potent indole derivative #5 (Mitochonic acid 5；MA-5) (Suzuki T et al. Tohoku journal Exp Med ;236:225-232:2015). The aim of this study was to clarify the effects of MA-5 in kidney injury to prevent CKD.

Free Research Field

腎臓内科