2015 Fiscal Year Final Research Report
Immunosuppression of anticancer agents containing PEGylated liposomes for liver transplantation.
| Project/Area Number |
26670079
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 血液型不適合肝移植 / 抗血液型抗体 / PEG修飾リポソーム / 抗がん剤 |
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| Outline of Final Research Achievements |
We have studied the issue of if a spontaneous tolerance of B cells responding to blood group antigens frequently could be induced in ABO-incompatible pediatric liver transplantation by intraperitoneal injection of anticancer agent containing PEGylated liposomes. Here, we evaluated the role of peritoneal B-1 cells in the induction of blood group antigen (BGA)-reactive IgM in mice. We found that peritoneal B-1 cells bound to and then took up PEGylated liposomes i.p. injected. The surface modification of PEGylated liposomes with BGA further induced the uptake of PEGylated liposomes by peritoneal B-1 cells. However, unfortunately, the intraperitoneal injection of BGA modified PEGylated liposomes containing anticancer agent failed to tolerance of B cells responding to ABO-blood group antigens in LT.
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| Free Research Field |
薬剤学
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