2016 Fiscal Year Final Research Report
The analysis of regulation mechanisms of astrocyte migration by Bone Morphogenetic Protein inhibitor
| Project/Area Number |
26670090
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 骨形成因子阻害因子 / アストロサイト / 脳梗塞 / グリア瘢痕 / エンドサイトーシス |
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| Outline of Final Research Achievements |
Astrocytes start to divide in the subventricular zone at the brain injury and promptly move to the damaged area. However, the mechanism of migration to the region is not well understood. We found one of BMP inhibitor is a strong repellent to the astrocytes. Strong assay using BMP inhibitor showed the avoidance of astrocyte A1 cells to the protein. In addition, the BMP inhibitor was incorporated into the early endosome and late endosome, indicating the novel mechanisms. Furthermore, three days after the middle cerebral artery occlusion, the factor was highly upregulated in the infarct region where astrocyte did not invade, and was secreted from NG2 positive microglia.
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| Free Research Field |
解剖学
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